Scientist, Antibody Drug Conjugate (ADC) & Purification Development at LOTTE Biologics

Production Support
Position Type
Regular Full-Time
Location : Location
US-NY-East Syracuse
Location : Postal Code


Lotte Biologics Company Logo


We are LOTTE BIOLOGICS! A new company, built on 80 years of tradition!


We embody our core values of being Inspired by Science, Embracing Diversity, Fostering Talent, and Connecting Lives. Our mission is to be the most trusted partner in the industry, with high standards of quality and continuous innovation, to reliably deliver benefits for patients worldwide.


We deliver therapies that make a Healthier World!


To help us meet our mission LOTTE BIOLOGICS is in need of a Scientist, Antibody Drug Conjugate (ADC) & Purification Development within our Manufacturing Sciences & Technology (MSAT) organization. The primary role of the ADC Scientist is to support the process development and production of ADCs as part of a multi-disciplinary team to advance ADC development and provide on-floor GMP support of manufacturing. The ADC Scientist will also support development of the facility and laboratory design, build out, start-up, and technical process transfer of the ADC process from laboratory to manufacturing for ADCs and other large molecule bioconjugates for various therapeutic areas. The ideal candidate will use knowledge of CMC elements related to bioconjugation throughout the product life cycle, leveraging technical expertise in conjugation chemistry and downstream unit operations including tangential flow filtration, dead-end filtration, and protein chromatography. The successful candidate will implement the design and execution of laboratory experiments in the development, optimization, and characterization of ADCs.

Remote Position


Min Compensation

USD $76,000.00/Yr.

Max Compensation

USD $113,000.00/Yr.





  • Degree in Biology, Chemistry, Biochemical or Chemical Engineering, or equivalent area of related industry experience in biologics downstream manufacturing, biochemistry, chemistry, or manufacturing technology: B.Sc/B.Eng with 5-7 years, M.Sc./M.Eng degree with 2-4 years, or Ph.D degree with 0-2 years of relevant industry experience
  • Experience with ADC chemistry, conjugation chemistry, reaction processes and purification process development is required
  • Demonstrated hands-on experience in the generation of antibody drug conjugates is preferred
  • Experience with CMC regulatory activities in relevant areas such as analytical characterization, formulation, and the general CMC scope for biologics and/or ADC molecules is preferred
  • Hands-on experience and knowledge of protein purification and characterization using laboratory-scale centrifugation, chromatography, normal-flow filtration, and tangential-flow filtration, as well as analytical techniques like Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, routine DNA/RNA techniques, protein expression and purification, sodium dodecyl sulfate polyacrylamide gel electrophoresis, ultraviolet-visible spectrophotometry, high-performance liquid chromatography, etc is preferred
  • Demonstrated experience working with Contract Development Manufacturing Organizations (CDMOs) is preferred

Specific Knowledge, Skills, Abilities, Etc.:

  • Experience designing and implementing experiments to evaluate purification and bioconjugation processes for ADCs in order to support development, execution, and technology transfer of purification and bioconjugation processes
  • Provide expertise to design and implement experiments and technical transfers to evaluate Biologics and bioconjugation process development including ADCs
  • Support efforts to identify and champion new chemistries and process technologies for bioconjugation
  • Develop, plan, and lead characterization of purification processes for antibodies and novel bioconjugation methodologies to improve ADCs including High Throughput Screening methods for purification development
  • Work collaboratively with SMEs and research scientists from other functions such as formulation, process, and analytical to understand relevant conjugation chemistries and to transition bioconjugation processes from research to CMC development, as applicable, to champion manufacturing in support of CMC activities of ADCs
  • Leverage process development experience to bring ADCs from Phase I through commercial, including experience in late-stage activities such as CMC risk assessments, process characterization, and process validation
  • Author and document experiments, complete data analysis, generate high-quality technical reports, lead risk management approaches and assessments, and support documentation for CMC submissions
  • Support ADC technical transfer to manufacturing and other functions including managing budget, timelines, resourcing, and planning
  • Collaborate and work with a diverse group of scientists/engineers across multiple therapeutic areas, chemistry, and process development to ensure timely progress in research projects and drive technological innovations
  • Provide technical on-floor support for production of GMP antibody and ADC batches

Physical Demands/Work Environment:

  • Laboratory-based position which requires appropriate levels of personal protective equipment (PPE). This role may require contact with biohazardous materials such as highly potent compounds, payload-linkers, and other hazardous chemicals including methotrexate, acids, and caustics. Powdered materials and high temperature liquids and solids may also be handled
  • Frequent repeated motions such as pipetting, lifting, bending, twisting, squatting, crouching, kneeling, climbing on step stools, and reaching may be required. This role may also require unassisted lifting (not to exceed 50 lbs).  Repetitive use of arms/hands/wrists and grasping may also be required
  • The position is based indoors and the individual will primarily be working with others, but also independently and alone at times in the laboratory
  • The office-based work will require sitting
  • The position is a team and project-based position that will require occasional shift work, weekends, evenings, and holidays
  • Dynamic, fast-paced, interactive, and entrepreneurial environment 


This position requires up to 10% of domestic and/or international travel.


Work Location:

East Syracuse, NY 


We believe that women, people of color, veterans and LGBTQ communities must participate in the work we do, so we strongly encourage applications from people with these identities or who are members of underrepresented communities.  If this is the work that you want to do in a culture of inclusion and excellence with the goal of making our world to be a healthier place, then please apply today! 


Company Website

Company Profile

LOTTE BIOLOGICS was established in 2022, and is headquartered in Seoul, South Korea. LOTTE BIOLOGICS entered the biologics CDMO business after acquiring Bristol Myers Squibb’s Syracuse biologics drug substance manufacturing site, as of January 1, 2023!


The newly established organization aims to become a Global Top 10 CDMO company in the biopharmaceutical industry.  With initial operations in 1948 in Japan, LOTTE has grown to become the fifth-largest conglomerate corporation in South Korea. LOTTE has various business units, including petro/fine chemicals, food, retail, hotels, electronics, construction, and IT. LOTTE has 30+ global locations across the US, Europe, and Asia.


An Equal Opportunity Employer

We do not discriminate based on race, color, religion, national origin, sex, age, disability, genetic information, or any other status protected by law or regulation. It is our intention that all qualified applicants are given equal opportunity and that selection decisions be based on job-related factors.


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