Principal Scientist Antibody Drug Conjugate and Purification Development at LOTTE Biologics

Position Type
Regular Full-Time
Location : Location
US-NY-East Syracuse
Location : Postal Code


Lotte Biologics Company Logo



A new company, built on 80 years of tradition 


We embody our core values of being Inspired by Science, Embracing Diversity, Fostering Talent, and Connecting Lives 

Our mission is to be the most trusted partner in the industry, with high standards of quality and continuous innovation, to reliably deliver benefits for patients worldwide 


We deliver therapies that make a Healthier World 



To help us meet our mission LOTTE BIOLOGICS is in need of a new Principal Scientist Antibody Drug Conjugate and Purification Development to lead the process development and production of ADCs as part of a multi-disciplinary team to advance ADC development and provide on-floor GMP support of manufacturing. The ADC Principal Scientist will also support development of the facility and laboratory design, build out, start-up, and technical process transfer of the ADC process from laboratory to manufacturing for ADCs and other large molecule bioconjugates for various therapeutic areas.  In this critical role you will;


  • drive the CMC elements related to bioconjugation throughout the product life cycle using technical expertise in conjugation chemistry and downstream unit operations including tangential flow filtration, dead-end filtration, and protein chromatography
  • lead the design and execution of laboratory experiments in the development, optimization, and characterization of ADCs
  • leverage direct experience designing and implementing experiments to evaluate purification and bioconjugation processes for ADCs in order to lead development, execution, and technology transfer of purification and bioconjugation processes
  • Develop, optimize, plan, and lead characterization of purification processes for antibodies and novel bioconjugation methodologies to improve antibody drug conjugates including High Throughput Screening methods for purification development
  • bring biologics from Phase I through commercial, including experience in late-stage activities such as CMC risk assessments, process characterization, and process validation, and provide technical experience for on-floor support for production of GMP antibody and ADC batches


It’s important to note that during facility build and start-up phases, the ADC Principal Scientist will serve as an individual contributor but will transition to lead a team of scientists and engineers.

Remote Position


Min Compensation

USD $91,000.00/Yr.

Max Compensation

USD $142,000.00/Yr.




To be successful in this role the Principal Scientist Antibody Drug Conjugate and Purification Development must have the demonstrated knowledge, skills, and abilities in the following; 

  • Degree in Biology, Chemistry, Biochemistry or Chemical Engineering, or equivalent area working in biologics downstream manufacturing or manufacturing technology: B.Sc/B.Eng degree with 9 years, M.Sc/M.Eng degree with 6 years, or Ph.D degree with 4 years of relevant industry experience 
  • Experience with ADC chemistry, conjugation chemistry, reaction processes and purification process development and demonstrated hands-on experience in the generation of antibody drug conjugates
  • Hands-on experience and knowledge of protein purification and characterization using centrifugation, chromatography, normal-flow filtration, and tangential-flow filtration, as well as analytical techniques like Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, routine DNA/RNA techniques, protein expression and purification, sodium dodecyl sulfate polyacrylamide gel electrophoresis, ultraviolet-visible spectrophotometry, and high-performance liquid chromatography
  • Experience working with Contract Development Manufacturing Organizations (CDMOs) is preferred

Work Location:

East Syracuse, NY 


We believe that women, people of color, veterans and LGBTQ communities must participate in the work we do so we strongly encourage applications from people with these identities or who are members of underrepresented communities. If this is the work that you want to do in a culture of inclusion and excellence with the goal of making our world to be a healthier place, then please apply today! 

Company Website

Company Profile

LOTTE BIOLOGICS was established in 2022, and is headquartered in Seoul, South Korea. LOTTE BIOLOGICS entered the biologics CDMO business after acquiring Bristol Myers Squibb’s Syracuse biologics drug substance manufacturing site, as of January 1, 2023!


The newly established organization aims to become a Global Top 10 CDMO company in the biopharmaceutical industry.  With initial operations in 1948 in Japan, LOTTE has grown to become the fifth-largest conglomerate corporation in South Korea. LOTTE has various business units, including petro/fine chemicals, food, retail, hotels, electronics, construction, and IT. LOTTE has 30+ global locations across the US, Europe, and Asia.


An Equal Opportunity Employer

We do not discriminate based on race, color, religion, national origin, sex, age, disability, genetic information, or any other status protected by law or regulation. It is our intention that all qualified applicants are given equal opportunity and that selection decisions be based on job-related factors.


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