Senior Engineer, Antibody Drug Conjugates at LOTTE Biologics

Job Locations US-NY-East Syracuse
Position Type
Regular Full-Time


Lotte Biologics Company Logo


LOTTE Biologics was established in 2022 and is headquartered in Seoul, South Korea. LOTTE Biologics entered the biologics Contract Development Manufacturing Organization (CDMO) business after acquiring Bristol Myers Squibb Syracuse biologics manufacturing site in 2022. The newly established organization aims to become a global top 10 CDMO in the biopharma industry.


LOTTE Biologics plans to make the East Syracuse, NY facility its North American hub of operations.  The transformation includes the creation of a facility to manufacture Antibody Drug Conjugates (ADC) as well as other classes of Bioconjugates.  The goal is to create a one-stop platform that offers everything from antibody drug production to chemical drug conjugation, as part of its efforts to become North America’s premier ADC contract manufacturing center.




LOTTE Biologics is seeking a Senior Engineer to support and drive the facility design, build out, start-up, qualification, and manufacturing processes for Antibody Drug Conjugates (ADCs) and other bioconjugate molecules.  The ideal candidate will have experience with common downstream unit operations such as tangential flow filtration, dead-end filtration, protein chromatography, and conjugation reactions.  This individual will work in a team-driven environment on customer projects to enable transfer to GMP manufacturing. During facility build and start-up phases this role will operate as an individual contributor.  As the facility transitions to the release phase, this role will transition to leading a team of engineers.


This position is located in East Syracuse, NY.



  • Provide technical input in support of equipment procurement including bid package preparation, bid evaluation, vendor selection.
  • Direct start-up and commissioning activities (FAT/SAT/IQ/CQ/) including the preparation of test protocols, test execution, troubleshooting, and change control, all per cGMP guidelines.
  • As Senior Engineer, you will manage operational activities in Downstream of Antibody Drug Conjugate manufacturing, e.g., tech transfer support, material planning, document and batch record preparation, training and troubleshooting, deviation handling.
  • Act as a functional lead for an interdisciplinary team of production personnel, supervisors and specialists and be accountable for the performance and results of assigned projects.
  • Guide and support activities for clinical and/or commercial manufacturing in one or more defined DSP areas, e.g., capture, intermediate purification, polishing or drug substance filling.
  • Ensure efficient operation of single-use and/or stainless-steel equipment for the purification of therapeutic proteins from either microbial or mammalian expression systems or for the manufacturing of therapeutic Bioconjugates like Antibody Drug Conjugates (ADCs)

Remote Position






  • BS or MS degree in Biotechnology, Bio-Chemical Engineering, Biochemistry or related Life Science subject is required.  Chemical Engineering degree preferred.
  • 5+ years of experience as an engineer in the operation, design, construction and/or start-up of biopharmaceutical facilities (cGMP manufacturing plants, pilot plants, laboratories, etc.) is required
  • Work experience in Antibody Drug Conjugates (ADCs) in the biotech/biopharma industry is preferred.
  • In-depth knowledge of downstream processing techniques like chromatography and TFF

Company Website

Company Profile

LOTTE BIOLOGICS was established in 2022, and is headquartered in Seoul, South Korea. LOTTE BIOLOGICS entered the biologics CDMO business after acquiring Bristol Myers Squibb’s Syracuse biologics drug substance manufacturing site, as of January 1, 2023!


The newly established organization aims to become a Global Top 10 CDMO company in the biopharmaceutical industry.  With initial operations in 1948 in Japan, LOTTE has grown to become the fifth-largest conglomerate corporation in South Korea. LOTTE has various business units, including petro/fine chemicals, food, retail, hotels, electronics, construction, and IT. LOTTE has 30+ global locations across the US, Europe, and Asia.


An Equal Opportunity Employer

We do not discriminate based on race, color, religion, national origin, sex, age, disability, genetic information, or any other status protected by law or regulation. It is our intention that all qualified applicants are given equal opportunity and that selection decisions be based on job-related factors.


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